THE STUDY OF CORRELATION BETWEEN LEIDEN V FACTOR AND METHYLEN TETRAHYDROFOLATE REDUCTASE ENZYME GENE MUTATIONS IN PRIMIGRAVIDA WITH MISSED ABORTION IN LATE FIRST TRIMESTER

Pregnancy is a hypercoagulable state secondary to an increase in coagulation factors, reduction naturally occurring anticoagulants, and impairment of fibrinolysis. losses were divided into preclinical, first trimester clinical, second trimester. A meaningfully increased rate preclinical pregnancy failure Leiden mutation carriers was found than no activated protein C deficiency patients. Another cause miscarriages inherited thrombophilia following damage the maternal factor V gene G1691A (Leiden mutation) prothrombin (G20210A mutation). These alterations are well studied test part routine diagnostics recurrent mis-carriages. In case V, both T1328C appear be important pathogenesis RM, mainly cases observed before 7th week gestation. The most common causes polymorphisms genes encoding (factor II), VII, MTHFR, plasminogen activator inhibitor, while C, S ant thrombin less common. finding link between FVL carrier early RPL would have significant implications for clinical practice, as it provide scientific rationale screening targeted thromboprophylaxisin affected women.